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2 edition of Cellular equilibria of a murine thymic lymphoma. found in the catalog.

Cellular equilibria of a murine thymic lymphoma.

Alastair James Riddell

Cellular equilibria of a murine thymic lymphoma.

by Alastair James Riddell

  • 178 Want to read
  • 20 Currently reading

Published by University of Birmingham in Birmingham .
Written in English


Edition Notes

Thesis (M.Sc.)-University of Birmingham, Dept of Anatomy.

ID Numbers
Open LibraryOL19633089M

rich thymoma Precursor T-cell acute lymphoblastic leukemia/lymphoblastic lymphoma (T-cell ALL/LBL) also is a tumor frequently occurring in the anterior mediastinum.4 When a large biopsy or resection specimen is available for review, the morphologic differentiation between thymoma and T-cell ALL/LBL, in general, is straightforward. Owing to. THE origin of lymphoma in the thymuses of mice is now well documented1. Of interest is the fact that regardless of the means used to induce the lymphoma (virus, chemicals, hormones, X-rays), the.

If murine T-cell lines are not available for screening, primary cultures of thymic lymphocytes placed in wells of a well plate at a concentration of 1x10 6 per mL of test medium containing concanavalin A (1μg/ mL) to stimulate rapid cell growth is adequate. In the presence of an optimal source of FBS, the number of cells should double every. Primary mediastinal (thymic) large B-cell lymphoma is a distinct type of diffuse large B-cell lymphoma involving the mediastinum, recognized in the WHO classification.: – Signs and symptoms. Superior vena cava syndrome occurs in %, and pleural or pericardial.

LYMPHOCYTIC neoplasms with characteristic thymic involvement occur spontaneously with high frequency in certain strains of mice1, and in other strains following X-irradiation2, chemical. @article{osti_, title = {Association of murine lupus and thymic full-length endogenous retroviral expression maps to a bone marrow stem cell}, author = {Krieg, A.M. and Gourley, M.F. and Steinberg, A.D.}, abstractNote = {Recent studies of thymic gene expression in murine lupus have demonstrated kb (full-length size) modified polytropic (Mpmv) endogenous retroviral RNA.


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Cellular equilibria of a murine thymic lymphoma by Alastair James Riddell Download PDF EPUB FB2

Becker FF. Role of the AKR gene locus AKv-1 in susceptibility to chemical induction of thymic lymphomas. Cancer Res. Oct 1; 50 (19)– Chattopadhyay SK, Cloyd MW, Linemeyer DL, Lander MR, Rands E, Lowy DR. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas.

Nature. Jan 7; ()–Cited by: Chattopadhyay SK, Cloyd MW, Linemeyer DL, Lander MR, Rands E, Lowy DR. Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas.

Nature. Jan 7; ()– Cloyd MW, Hartley JW, Rowe WP. Lymphomagenicity of recombinant mink cell focus-inducing murine leukemia by: Nucleophosmin-anaplastic lymphoma kinase (NPM–ALK) positive anaplastic large cell lymphoma (ALCL) is considered as a peripheral T-cell lymphoma and is associated with the t(2;5)(p23;q35) translocation, identified to be the fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM1 (ref.

1).ALCL is defined by expression of the CD30 marker of activated B and T cells and, in some cases, T Cited by:   15 AKR-thymic lymphoma lines were shown to carry the T cell markers Thy and MSLA, whereas the B cell marker MBLA was absent from the cell surface.

These 15 T cell tumors were tested for binding of EA-rosettes (ORBC coupled with anti-ORBC antibody). 11 tumors expressed Fc-receptors on the cell : P.H.

Krammer. A number of T-cell-specific cell-surface antigens, including CD4, CD8, CD3, TL, IL-2R, MEL and H-2K, have been employed to classify mouse thymic lymphomas, and heterogeneity attributed to either a continuous spectrum of mature and immature phenotypes (3, 6, 27, 31), or to the cortical or medullary origin of the lymphoma cell within the by: Cellular Immunology VolumeIssue 1, AugustPages Thymic lymphomas mediate non-MHC-restricted, TNF-dependent lysis of the murine sarcoma WEHI ☆.

CELLULAR IMMUNOL () Murine Thymic Lymphomas as Model Tumors for T-Cell Studies T-Cell Markers, Immunoglobulin and Fc-Receptors on AKR Thymomas PETER H. Cellular equilibria of a murine thymic lymphoma. book KRAMMER, RONALD CiTRONBAUM,1 STANLEY E.

READ,2 LUCIANA FORNI, AND ROSEMARIE LANG The Basel Institute for Immunology, Basel, Szvifserland Received Septem Fifteen AKR thymic lymphoma. The incidence of spontaneous thymic lymphoma has been studied in crosses between AKR/J and RF/J mice.

AKR mice develop a high incidence of this disease. RF mice transmit a marked resistance to development of the disease to F 1 hybrid mice of the AKR × RF cross.

This resistance is associated with a reduction of endogenous ecotropic and. The cellular receptor for murine thymic stromal lymphopoietin (TSLP) was detected in a variety of murine, but not human myelomonocytic cell lines by radioligand binding.

cDNA clones encoding the receptor were isolated from a murine T helper cell cDNA library. TSLP receptor (TSLPR) is a member of the hematopoietin receptor family. Simultaneously to their appearance, several components of thymic lymphopoiesis are altered: the prothymocyte activity is drastically reduced in the bone marrow (Boniver et al.

; Van Bekkum et al. ); in the thymus, thymocyte subpopulations are modified (Rongy et al. ) and some properties of the thymic epithelium are altered. Mediastinal lymphoma is also referred to as thoracic or thymic lymphoma. It is reported to be the most common neoplasm affecting the thoracic cavity.

33,– Horses between 2 and 30 years of age can be affected, with a mean age of 10 years. There is no breed predilection but geldings and stallions are seemingly affected more. That these retroviruses and their interactions with T lymphoma cell receptors might be involved in the pathogenesis of murine leukemia was suggested by two kinds of experiments: First, only the leukemogenic viral isolates bound specifically to lymphoma cell receptors, while nonleukemogenic but closely related viral preparations bound less well.

Cloyd MW, Hartley JW, Rowe WP. Cell-surface antigens associated with recombinant mink cell focus-inducing murine leukemia viruses. J Exp Med. Mar 1; (3)– [PMC free article] McGrath MS, Weissman IL. AKR leukemogenesis: identification and biological significance of thymic lymphoma receptors for AKR retroviruses.

Cell. Chattopadhyay SK, Cloyd MW, Linemeyer DL, Lander MR, Rands E, Lowy DR () Cellular origin and role of mink cell focus-forming viruses in murine thymic lymphomas. Nature –31 PubMed CrossRef Google Scholar.

Expression of programmed cell death 1 ligand 2 (PD-L2) is a distinguishing feature of primary mediastinal (thymic) large B-cell lymphoma and associated with PDCD1LG2 copy gain. The American journal of surgical pathology, 38(12), Immune Network The Differential Staging of Murine Thymic Lymphoma Cell Lines,R and EL-4 Jong Seok Chae 1, Hae-jung Kim1, Weon Seo Park1, Youngmee Bae and Kyeong Cheon Jung2 1Department of Pathology, Kangwon National University College Medicine, Chunchon, Korea; 2Department of Pathology, Hallym University College Medicine, Chuncheon, Korea.

The directly transforming murine retrovirus, AKT8, was isolated from a spontaneous AKR thymoma and carries the cell-derived viral oncogene, akt. We have now shown that this virus produces thymic lymphomas after inoculation of susceptible mouse strains.

In the present study, primary thymic lymphomas induced by DMBA-LV in CFW/D, NIH Swiss, C3H/Bi/Ka, and C57BL/Ka mice were assessed for the presence of newly integrated type B retroviral DNA. All 46 primary thymic lymphomas examined contained one to four newly acquired murine. Evidence has indicated that two soluble factors are essential for a T-cell proliferative response to antigen or lectin1–3.

One such factor, thought to be of T-cell origin, is distinguished by. Abstract. We have applied the Kiel Classification of human lymphomas (Lennert and Feller ) to a series of mouse lymphomas (Table 1).

In our survey, some came from other sources but most were from mice congenic for ecotropic murine leukemia virus induction loci and expressing high levels of endogenous leukemia viruses. Low-grade B-cell lymphoma of mucosa-associated lymphoid tissue arising in the thymus. A thymic lymphoma mimicking myoepithelial sialadenitis.

Am J Surg Pathol. Apr;14(4)T-acute lymphoblastic leukemia (T-ALL) and T- lymphoblastic lymphoma (T-LBL) are neoplasms of immature T-cell precursors or lymphoblasts. T-ALL is less common than B-acute lymphoblastic leukemia (B-ALL) and accounts for approximately 15% of all childhood acute lymphoblastic leukemia (ALL) cases.

1, 2 These neoplasms tend to occur in older adolescents, with a male predominance.Sakura Y, Ogiu T, Imamura N, Furuta K, Matsuoka C, Odashima S () Development of thymic lymphomas by oral administration of N-nitroso-N-propylurea and establishment of transplantable lines of thymic lymphoma in F rats.

JNCI – PubMed Google Scholar.